It appears to have the potential to help decrease bodyfat. In a recent study by Morimoto et al (2005), raspberry ketone was fed at various dosages to growing mice for 10 weeks. Mice fed a high-fat diet (to induce obesity) plus one or two percent raspberry ketone (~ 10,000 mg per kg bodyweight) gained less bodyfat than control animals. Raspberry ketone also decreased the weights of the liver and visceral adipose tissues (epididymal, retroperitoneal, mesenteric)—i.e., fat around the organs.

Raspberry ketone anti-obesity effects appear to be due to at least two mechanisms: 1) decreased absorption of dietary fat and 2) increased norepinephine-induced lipolysis (fat burning). Regarding decreased fat absorption, raspberry ketone given at concentrations of 1 to 20 mg/mL after oral administration of corn oil reduced the elevation of plasma triacylglycerol in mice and inhibited pancreatic lipase in rats. This suggests raspberry ketone suppresses dietary fat absorption by inhibiting trioleoylglycerol hydrolysis.

Regarding enhanced lipolysis, raspberry ketone did not bind to beta- 1, 2, or 3-adrenergic receptors but instead enhanced glycerol release in a concentration-dependent manner. This is particularly evident at a concentration of 10-3 M, where raspberry ketone also increased the translocation of hormone sensitive lipase (HSL, the rate limiting enzyme for lipolysis) from the cytosol to the lipid droplets in fat cells.

Finally, as reported by Morimoto et al (2005), raspberry ketone may also increase brown adipose tissue thermogenesis and lower the respiratory quotient, the end result of which is increased thermogenesis (burning calories through heat) and oxidation of bodyfat (fat burning).

I use 500mg 3 times a day.,
Jason Adams